Hormone Therapy Treatment for Cancer Benefits, Side effects
Hormone Therapy Treatment for Cancer Benefits & Side effects
Hormone therapy treatment of cancer
In order to understand the basic hormone therapy of cancer. In the case of hormone therapy, the man of research is endless. Apart from cancer, we are discussing hormone and other things that happen inside your body. When we come to science in breast cancer there is a fine line between helpful and being confusing. Therefore in science, we can discuss most common types of hormone therapy a company has developed breast cancer index. BCI examines a specific gene signature in cancer to identify if you are likely to get benefit from extending long term anti-estrogen therapy beyond five years.
In order to understand your hormone first, we understand about an endocrine system made up of organs such as the pancreas, ovaries, thyroid, and adrenal glands. Our endocrine system releases the hormone under the bloodstream and signals other parts of the body. Ovaries produce mainly estrogen, testosterone, and progesterone. While our thyroid is made up of triiodothyronine and thyroxine. Thyroxine is also known as T3 and T4 hormones. So now we discuss the meaning of hormone. The hormone is a chemical messenger that gives instructions to different parts of our body. T3 and T4 hormone regulate our body temperature, metabolism, and heart rate.
For estrogen control, your ovaries sexual development and other tissues such as fat cells, liver, and adrenal glands produce estrogen which effects our cholesterol levels, bone density, and brain function. Estrogen can affect our heart, skin and other tissues inside both men and women. Hormones are responsible for lots of different things physical changes in our body.
Now we know how hormones of our body are affected by cancer. Hormones include specific parts of our body called a receptor. Cancer cells are included in our receptor which ties with tumor growth because these cancer hormones were sensitive. When our body will releases the hormones flow to our bloodstream and combining with the specific cell receptors. Each hormone corresponds to the different receptors like keys made for a lock. Estrogen binds the receptor on breast cancer cells that locks a signal for the lock to grow and multiply. Now there are few major hormones that can feel breast cancer growth namely estrogen and progesterone. If the doctor says that your breast cancer is ER-positive. In fact, eighty percent of all breast cancer considered as ER-positive and sixty-five percent of breast cancer is PR positive.
How this hormone therapy works
The hormone therapy depends upon the receptor status of breast cancer. Doctors try to prevent hormone production and blood receptors they need to grow. The first types of hormone therapy are ER-positive breast cancer thereby blocking estrogen for reaching cancer cells. This is the purpose of selective estrogen receptor modulators. Tamoxifen is the most common form of selective estrogen receptor modulator which binding with estrogen receptor and breast cancer cells. Tamoxifen is used as the most common estrogen therapy this means tamoxifen blocks estrogen action effectively inside the breast cells. Estrogen effects on other cells inhibited.
The second type of hormonotherapy stopping the body from producing estrogen altogether. We can call this hormonotherapy as aromatase inhibitors. Aromatase inhibitors work by blocking the function of enzymes it estrogen production however only post menopause women prescribed these medicines by the doctors. The way you are asking, however, woman womb producing estrogen from ovaries after menopause. Our adrenal, liver, fatty tissue and other tissues continuously producing menopause. Hormonotherapy is a very large topic. There are various types of treatment which are used to treat hormone breast cancer. Knowledge is important and crucial is used to control breast cancer.
The benefit of Harmontherapy to treat cancer Hormone therapy involves
Medication in order to prevent us from cancer cells from getting the hormone they need to grow. Doctor and physicians can use a different strategy in order to prevent us from cancer present inside the hormones. The doctor uses the surgical operation to remove the gland that is responsible for the production of the hormone. While physician use hormone therapy with other surgical operation like chemotherapy and radiation therapy to solve the production of the hormone inside the patient body.
Side effects of hormone therapy
Treatment of hormone therapy interferes with the functioning of specific hormones inside the body depending on the type of cancer and administered specific drugs and use some medication in the treatment of cancer uses side effects. Hormone therapy drugs are also provided to those patients who suffer Some of the side effects that patients suffer from prostate cancer while taking hormone therapy drugs to include vaginal dryness.
Some other side effects that patient suffer while using hormone therapy drugs
- Hot flashes
- Loss of bone density
- Weight gain
- Mood swings
- Nausea and vomiting
Hormone therapy for prostate cancer
Prostate cancer is the uncontrolled growth of cells in the prostate. It is detected by PSA blood test and digital rectal exam (DRE) and confirmed by using biopsy which allows the doctor to look at prostate cells under the microscope. The prostate cancer depends upon the stage and extent of disease. The different option may be considered for different types of diseases. In general term prostate cancer may be a concern with three types
- Locally advanced cancer
- Cancer that is come back after treatment (recurrent)
- Cancer that has spread to the other parts of the body (metastatic)
There is the number of treatment options is available which is used to treat prostate cancer. The treatment recommended by a doctor or depending upon stage and grade of prostate cancer in the patient's general health and age. For the early stage of prostate cancer, the aim of treating cancer is cured. For the later stage of prostate cancer, the aim of treatment is to extend the life and help cancer patient to relieve from symptoms. Standard treatment of prostate cancer include
- Surgery: Removing cancer in an operation.
- Radiation therapy: Using high-energy rays to kill cancer cells, shrink tumors
- Active surveillance: Being closely watched and examined regularly.
Hormone therapy does not cure prostate cancer but it slows down the growth of cancer for a period of time. It can be used for both localized and advanced prostate cancer. Sometimes uses alone when the patient is not suitable for other treatments. It optimized the results of other treatments by using surgery and radiation before treatment. It is known as neoadjuvant or after treatment is also called as adjuvant therapy.
Active surveillance Cancer is spread to other parts of the body is to learn cancer is under control. Hormonotherapy treatment aimed to decrease the production of or block the action of testosterone.
It is originated from the research in the 1940s that confirmed testosterone withdrawal from the body destroyed prostate cancer and shrunk prostate tumor.
Testosterone is the male sex hormone which is responsible for
- Muscle mass
- Production and maturation of sperm
- Male physical characteristics
- Sex drive
- Majority produced by testicles, small amounts made inside the adrenal gland.
The organ that says that birth and kidney. When the bran of patient detects a low level of testosterone in the gland hypothalamus gland inside the brain releases a substance called LHRH. LHRH travels to a pituitary gland stimulate the releasing of other hormone called LH.LH travels inside the bloodstream and stimulates the production of testosterone inside the testicles and adrenal glands.
Hormone therapy for breast cancer
Hormone therapy is used in seventy percent of women who suffered from breast cancer whose tumor contain specifically expressive body estrogen receptor. Then receptor makes them potentially sensitive to these medications. These block the action of estrogen used only in chemotherapy or radiation therapy incredible well tolerated. The anti-estrogen and it is used in breast cancer. Blocking the action of estrogen is one of the oldest and most effective strategies in the treatment of breast cancer. It is first targeted therapy that used for the specific characteristics of cancer removed from the patients that is the presence of estrogen receptor in order to help the direct treatment of cancer. It is located inside the nucleus normal breast cells and about 75 percent of breast cancer cells. When estrogen binds to the receptor, the receptor “couples” or dimerizes with the second receptor and activates the DNA inside the cell nucleus, causing cell division and tumor growth. While estrogen in the target cell binds to the estrogen receptor. The receptor has the ability to couple or dimerizes bind to the DNA in the nucleus cell and create a protein which promotes cell growth. As you see in the right however non-target cell contains no estrogen receptor and therefore its growth is independent in the present in estrogen. When estrogen binds to the receptor, it couples or dimerizes and send its signal to the DNA of the cell to cause cell growth. The use of anti-estrogens in breast cancer blocking the action of estrogen can help to kill breast cancer cells that contain the estrogen receptors
There are three major hormone therapy drugs that are used inside the treatment of cancer
- Aromatase inhibitor
Doctor know how each of the hormone therapy drugs works to block estrogen activity inside the breast cancer cells. Tamoxifen is the hormone therapy drugs is structurally similar to estrogen and binds weekly to the estrogen receptor. It blocks estrogen inside the body from binding to the receptor. Since it binds weekly that does not allow the receptor to dimerize the action of estrogen and the breast is blocked. However, tamoxifen acts like estrogen in other organs such as bone and uterus inside the patient body for cholesterol. Tamoxifen is used for the patient who suffers from breast cancer for the prevention in high- risk patients that is patients with a strong family history but no personal history of breast cancer. Tamoxifen is also used in pre-invasive breast cancer after appropriate local therapy. It is used or the prevention treatment of invasive breast cancer in pre-menopausal and post-menopausal patients. This drug works equally well in both groups since it blocks the receptor present in the cancer of both ages of the patients. Prior to surgery, it helps to shrink cancer inside the patient body.
Hormone therapy for endometrial cancer
It uses hormone or hormone-blocking drugs to treat cancer. It is not the same as that of hormone therapy that is given by the doctor to the patients who suffer from menopausal hormone therapy. It is also used in endometrial cancer that is the advanced stage of cancer.
Hormone therapy is used in the treatment of endometrial cancer are
- Luteinizing hormone-releasing hormone agonists
- Aromatase inhibitors
At this time best hormone therapy is used in the treatment of endometrial cancer is not found for the patients who suffer from endometrial cancer.
Hormone therapy for ovarian cancer
Hormone therapy uses hormone therapy drugs to fight cancer. This therapy is used to treat epithelial ovarian cancer. It is most often used to treat ovarian LHRH is used in lower estrogen levels in women. LHRH contain goserelin and leuprolide. These hormone therapy drugs are injected inside the patient body up to one to the three months. But in LHRH it can cause some of the side effects inside the patient body such as hot flashes and vaginal dryness. Hormone therapy is used for the hormone in medical treatment.
Some of the hormone therapy treatment is used to treat common types of cancer are
- Abiraterone hormone therapy is used to treat prostate cancer
- Anastrozole hormone therapy is used to treat breast cancer
- Exemestane hormone therapy is used to treat breast cancer
- Fulvestrant hormone therapy is used to treat breast cancer
- Letrozole hormone therapy is used to treat breast cancer
- Leuprolide hormone therapy is used to treat breast, prostate and uterine cancer
- Tamoxifen hormone therapy is used to treat breast cancer
- These therapies are used in the treatment of cancer